HIV drug resistance: genotypic assays and their possible applications
نویسندگان
چکیده
منابع مشابه
Geno2pheno: Interpreting Genotypic HIV Drug Resistance Tests
nonnucleoside reverse transcriptase (RT) inhibitors (NRTI and NNRTI, respectively) and protease inhibitors (PI). (See the “Abbreviations” sidebar for other abbreviations in this article). Even with the currently recommended combination therapies consisting of three to five drugs, few patients achieve longterm suppression of plasma virus levels below detectable limits. Drug resistance1 is a majo...
متن کاملHIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and middle-income countries (LMICs) hardest hit by the HIV-1 pandemic. Genotypic drug resistance testing could facilitate the choice of initial ART in areas with rising transmitted drug resistance (TDR) and enable care-providers to determine which ind...
متن کاملMining complex genotypic features for predicting HIV-1 drug resistance
MOTIVATION Human immunodeficiency virus type 1 (HIV-1) evolves in human body, and its exposure to a drug often causes mutations that enhance the resistance against the drug. To design an effective pharmacotherapy for an individual patient, it is important to accurately predict the drug resistance based on genotype data. Notably, the resistance is not just the simple sum of the effects of all mu...
متن کاملHIV-1 genotypic drug resistance interpretation rules - 2009 Spanish guidelines.
Interpreting the results of drug resistance tests for HIV-1 is one of the most difficult tasks for both clinicians and virologists. There are many amino acid changes in viral proteins influencing the susceptibility to specific drugs, causing loss of activity or conversely hypersusceptibility. Moreover, the results of interactions derived from complex mutational patterns are difficult to predict...
متن کاملThe calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance
UNLABELLED The calibrated population resistance (CPR) tool is a web-accessible program for performing standardized genotypic estimation of transmitted HIV-1 drug resistance. The program is linked to the Stanford HIV drug resistance database and can additionally perform viral genotyping and algorithmic estimation of resistance to specific antiretroviral drugs. AVAILABILITY http://cpr.stanford....
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 1998
ISSN: 1368-4973
DOI: 10.1136/sti.74.4.243